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matrine
- Development stage
- Unknown
- Lead developer
- Chengdu First Pharmaceutical
- Modality
- Nucleic Acid-Directed Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules, Covalent Small Molecules → Small Molecules, Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules
01
Overview
Matrine is a quinolizidine alkaloid extracted from the roots of Sophora flavescens and related plants. It is a small molecule with diverse pharmacological activities including anti-inflammatory, anti-tumor (anticancer), antiviral, antioxidant, and immunomodulatory effects. Mechanistically, matrine acts as an agonist at kappa opioid receptors and mu opioid receptors. It also modulates multiple cellular pathways such as TGF-beta/Smad signaling and apoptosis-related proteins (e.g., Bcl-2 family), contributing to its anticancer and anti-inflammatory properties. Clinically in China, it is used for chronic hepatitis B (to improve elevated transaminases and abnormal bilirubin) and as an adjunct in cancer therapy during radiotherapy or chemotherapy[1][2][3][8].
- Brand names
- 永新
- Other names
- 苦参素苦参碱Matridin-15-oneMatridin15-oneMatridin 15-one(+)-Matrine
02
Targets
KOR (Kappa opioid receptor)MOR (Mu opioid receptor)
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