matrine methanesulfonate

Matrine methanesulfonate is the methanesulfonate salt of matrine, a quinolizidine alkaloid naturally occurring in the *Sophora* genus of plants, such as *Sophora flavescens*. Developed by Tianjin Hongri Pharmaceutical, the drug is primarily being evaluated for the treatment of severe sepsis. Its mechanism of action involves potent anti-inflammatory activity, characterized by the inhibition of pro-inflammatory cytokine production (such as TNF-α, IL-1β, and IL-6) and the modulation of signaling pathways like NF-κB and TLR4. By dampening the systemic inflammatory response, it aims to mitigate the organ damage associated with septic shock. The methanesulfonate salt form is utilized to enhance the solubility and stability of matrine for injectable administration.

Other names

matrine mesylate