Clinical trials
Full profile accessFollow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
matured hop bitter acids
- Development stage
- Unknown
- Lead developer
- Kyowa Kirin
- Modality
- Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
- Administration
- Oral
01
Overview
Matured hop bitter acids (MHBA) are a group of oxidized compounds, including 4-hydroxyisohumulones, produced by the aging of hop α-acids (humulones). Developed and researched primarily by Kirin Holdings, MHBA are being investigated for their potential neuroprotective and cognitive-enhancing properties. The mechanism of action involves the activation of bitter taste receptors (TAS2Rs) in the gastrointestinal tract, which stimulates the vagus nerve and subsequently modulates brain function by increasing dopamine levels in the hippocampus and prefrontal cortex and reducing neuroinflammation. MHBA have been evaluated in clinical trials for improving memory and attention in healthy older adults and are currently being studied for their ability to mitigate cognitive decline in patients with Parkinson's disease.
- Other names
- matured hop extractmatured hop bitter acids extract
02
Targets
PPARG (Peroxisome proliferator-activated receptor gamma)TAS2R8 (Taste receptor type 2 member 8)TAS2R1 (Taste receptor type 2 member 1)TAS2R10 (Taste receptor type 2 member 10)
Beyond the preview
Go deeper on matured hop bitter acids.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Full profile accessExplore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Full profile accessTrace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Full profile accessExplore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Full profile accessCompare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Full profile accessConnect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on matured hop bitter acids.