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mavatrep
- Development stage
- Phase 1
- Lead developer
- Janssen Research & Development
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Mavatrep is a small molecule, orally active, selective and potent antagonist of the transient receptor potential vanilloid subtype 1 (TRPV1) receptor. It acts as a competitive antagonist at TRPV1, which is involved in pain and inflammation signaling pathways. Developed as an investigational analgesic, mavatrep has been studied primarily for the treatment of pain conditions such as osteoarthritis and other chronic pain disorders. Clinical studies have shown that it can modulate heat pain perception and capsaicin-induced flare responses in humans. The drug was originally developed by Johnson & Johnson Pharmaceutical Research & Development[1][2][3][4][5][6].
- Other names
- mavatrep956274-94-5Mavatrep [USAN]Mavatrep (USAN)MAVATREP [INN]MAVATREP [MI]MAVATREP [WHO-DD]
02
Targets
TRPV1 (Transient receptor potential cation channel subfamily V member 1)
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