maxacalcitol

Maxacalcitol is a synthetic vitamin D3 analog and vitamin D receptor activator (VDRA) used as a pharmaceutical drug. It is administered topically for the treatment of psoriasis vulgaris and related skin disorders, and intravenously for secondary hyperparathyroidism in patients undergoing hemodialysis. Maxacalcitol inhibits the proliferation of epidermal keratinocytes, improving epidermal thickening in conditions like psoriasis, ichthyosis, palmoplantar keratoderma, and palmoplantar pustulosis. In parathyroid cells, it suppresses parathyroid hormone (PTH) secretion without significantly increasing serum calcium levels. Its mechanism of action involves binding to the vitamin D receptor (VDR), modulating gene expression involved in cell proliferation and differentiation[1][5][6][7][8].

Brand names

Oxarol

Other names

22-OxacalcitriolOCTmaxacalcitol