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MBD2 siRNA
- Development stage
- Preclinical
- Lead developer
- Huazhong University of Science and Technology
- Modality
- Chemically Modified siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Conjugated siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics
01
Overview
MBD2 siRNA is a small interfering RNA (siRNA) designed to target and silence the expression of methyl-CpG-binding domain protein 2 (MBD2). MBD2 is an epigenetic reader that binds to methylated DNA and mediates transcriptional repression. In preclinical studies, MBD2 siRNA has been investigated for its potential to reverse age-related metabolic disorders by restoring beige adipocyte differentiation, as well as for treating allergic airway inflammation (asthma) and suppressing tumor metastasis.
- Other names
- Mbd2 siRNAMbd-2 siRNAMbd 2 siRNAmethyl-CpG-binding domain protein 2 small interfering RNA
02
Targets
BMP2 (Bone morphogenetic protein 2)DDB2 (Damage-specific DNA-binding protein 2)Methyl-CpG binding domain protein 2 mRNA (MBD2 mRNA)MBD2 (Methyl-CpG-binding domain protein 2)
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