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MBI-06

Development stage: Unknown
Lead developer: Matrix Biomed
Modality: Small Molecules

Overview

MBI-06 is a Tempol-based small molecule therapeutic developed by Matrix Biomed. It is designed to modulate the activity of Hypoxia-Inducible Factor 1 (HIF-1) and Hypoxia-Inducible Factor 2 (HIF-2), which are master transcription factors that regulate the cellular response to hypoxia and are implicated in cancer progression and the development of chemotherapy-induced side effects. MBI-06 is specifically being developed to mitigate toxicities associated with doxorubicin, a common anthracycline chemotherapy agent. The drug is currently in Phase 2 clinical development.

Targets

HIF1A (Hypoxia-inducible factor 1-alpha)EPAS1 (Hypoxia-inducible factor 2-alpha)

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