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MBP-Y004
- Development stage
- Preclinical
- Lead developer
- Mebiopharm
- Modality
- Nanoparticles → Drug Delivery Systems, Small Molecules
- Administration
- Intravenous
01
Overview
MBP-Y004 is a preclinical-stage nanoparticle drug delivery system developed by Mebiopharm, utilizing their proprietary Transferrin-conjugated Liposome (Tf-liposome) technology. The therapeutic consists of the microtubule-stabilizing agent paclitaxel encapsulated within liposomes that are surface-modified with transferrin ligands. This design targets the transferrin receptor (TfR/CD71), a protein frequently upregulated in malignant tissues such as ovarian, breast, and non-small cell lung cancers to meet increased iron demands. By binding to TfR, MBP-Y004 is internalized via receptor-mediated endocytosis, potentially enhancing the concentration of paclitaxel within tumor cells while minimizing exposure to healthy tissues, thereby improving the therapeutic index over conventional paclitaxel.
- Other names
- Tf-liposome-paclitaxeltransferrin-conjugated paclitaxel liposome
02
Targets
TFRC (Transferrin Receptor)TUBB (Tubulin (alpha and beta subunits))
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