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MBX-116

Development stage: Preclinical
Lead developer: mbiomics
Modality: Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics
Administration: Oral

Overview

MBX-116 is an investigational live biotherapeutic product (LBP) developed by mbiomics, consisting of a defined consortium of bacterial strains. It is being developed as a co-therapy for the treatment of advanced melanoma, with the aim of modulating the host's microbiome to improve the efficacy of existing treatments such as immune checkpoint inhibitors. The drug is currently in the IND-enabling phase, supported by a Series A financing round that concluded in April 2026, with plans to initiate a Phase 1B clinical trial.

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