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Mc-Gly-Gly-Phe-Gly-PAB-OH
- Development stage
- Preclinical
- Lead developer
- Chongqing Sintaho
- Modality
- Peptides, Cytotoxic ADCs → Antibody-Drug Conjugates (ADCs) → Antibody Conjugates → Antibody-Based Therapeutics
- Administration
- Intravenous
01
Overview
Mc-Gly-Gly-Phe-Gly-PAB-OH is a specialized peptidic linker intermediate used in the development and manufacture of antibody-drug conjugates (ADCs). The molecule comprises a maleimidocaproyl (Mc) moiety for thiol-specific conjugation to antibodies, a tetrapeptide sequence (Gly-Gly-Phe-Gly) that is selectively cleaved by lysosomal enzymes such as cathepsin B, and a para-aminobenzyl alcohol (PAB) self-immolative spacer. This linker architecture is designed to maintain systemic stability while ensuring the efficient intracellular release of a cytotoxic payload upon internalization into target cells. It is a key component in the synthesis of several high-profile ADCs, including trastuzumab deruxtecan (Enhertu), and is offered by Chongqing Sintaho as a catalog intermediate for ADC research and development.
- Other names
- Maleimidocaproyl-glycyl-glycyl-phenylalanyl-glycyl-p-aminobenzyl alcoholMc-GGFG-PAB-OH
02
Targets
CTSB (Cathepsin B)
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