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Mcl-1 shRNA

Development stage: Preclinical
Lead developer: Dana-Farber Cancer Institute
Modality: Viral-delivered RNAi → In Vivo RNAi → Gene Silencing → Gene Therapies, RNA Therapeutics → Nucleic Acid Therapeutics
Administration: Intratumoral

Overview

Mcl-1 shRNA is a short hairpin RNA (shRNA) designed to silence the expression of the anti-apoptotic protein Mcl-1 (Myeloid Cell Leukemia 1) through RNA interference. In the provided context, it is delivered via a lentiviral vector to investigate the survival dependence of small cell lung cancer (SCLC) cell lines on Mcl-1. Mcl-1 is a member of the Bcl-2 family that inhibits apoptosis; its overexpression is a known mechanism of resistance to Bcl-2/Bcl-xL inhibitors such as ABT-737. By depleting Mcl-1, this shRNA induces apoptosis in Mcl-1-dependent cells, serving as a critical tool for target validation and for exploring therapeutic strategies to overcome drug resistance in SCLC.

Other names: Mcl-1 knockdownMcl1 knockdownMcl 1 knockdownlentiviral-based shRNA targeting Mcl-1

Targets

MCL1 (Myeloid cell leukemia sequence 1)

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