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MCM vaccine
- Development stage
- Preclinical
- Lead developer
- University of Florida
- Modality
- Vaccines & Immunotherapeutics, mRNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Hydrogel Systems → Drug Delivery Systems
- Administration
- Subcutaneous
01
Overview
**MCM vaccine** is an investigational, preclinical tumor-mRNA cancer vaccine developed at the University of Florida for glioblastoma and glioma. It consists of total tumor-derived mRNA organized in an \"onion-like\" microgel-chemokine-mRNA complex and administered subcutaneously. In a murine intracranial glioma model, the formulation promoted intratumoral immune activation, including dendritic-cell and natural-killer-cell recruitment, T-cell activation and infiltration, and pro-inflammatory M1-like microglial reprogramming. Its antitumor activity was associated with tumor CCL4 upregulation and signaling through the CCL4-CCR5 axis; CCL4 blockade eliminated the observed survival benefit.
- Other names
- MCMMCM vaccinemicrogel-chemokine-mRNA complex
02
Targets
CCR5 (C-C chemokine receptor type 5)CCR3 (C-C chemokine receptor type 3)CCL4 (C-C motif chemokine ligand 4)
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