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MCMV-B5
- Development stage
- Preclinical
- Lead developer
- Lions Eye Institute
- Modality
- Vaccines & Immunotherapeutics
- Administration
- Intraperitoneal
01
Overview
MCMV-B5 is a preclinical recombinant murine cytomegalovirus (MCMV) viral vector vaccine candidate designed to boost and prolong immunity against malaria. It is engineered to express the *Plasmodium chabaudi* merozoite surface protein 1 (MSP-1) CD4+ T-cell epitope B5. Developed by researchers at Rutgers New Jersey Medical School, the University of Texas Medical Branch, and collaborating institutions, MCMV-B5 acts as a booster to live malaria vaccines. It functions by stimulating and maintaining parasite-specific effector T cells (Teff) and effector memory T cells (Tem), while the MCMV vector itself provides non-specific adjuvant properties through prolonged stimulation of interferon-gamma (IFN-γ).
- Other names
- murine cytomegalovirus encoding P. chabaudi MSP-1 epitope B5murine cytomegalovirus encoding Plasmodium chabaudi MSP-1 epitope B5
02
Targets
MSP1 (Merozoite surface protein 1)
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