Drug intelligence / Profile preview

mCTLA4-mFc

Development stage
Unknown
Modality
Fc-Fusion Proteins → Carrier/Scaffold Proteins → Recombinant Proteins and Enzymes
Administration
Intraperitoneal, Intravenous
01

Overview

mCTLA4-mFc appears to be a **preclinical murine CTLA4-Fc fusion protein** consisting of the extracellular domain of mouse cytotoxic T-lymphocyte-associated protein 4 fused to a mouse immunoglobulin Fc region. Based on the biology of CTLA4-Fc reagents, it would be expected to bind the B7 ligands CD80 and CD86 on antigen-presenting cells, thereby blocking CD28-mediated co-stimulation and suppressing T-cell activation. The name format and the limited public evidence suggest this is a research reagent or internal preclinical construct rather than a marketed pharmaceutical product; publicly available information is insufficient to confidently assign a specific developer, manufacturer, clinical indication, dosage form, route, or development program.

Other names
mouse CTLA4-mouse Fc fusion proteinmurine CTLA4-murine Fc fusion proteinmCTLA-4-mFcmCTLA4-mFcmCTLA 4-mFc
02

Targets

CD86 (T-lymphocyte activation antigen CD86)CD80 (T-lymphocyte activation antigen CD80)

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