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mCura1
- Development stage
- Preclinical
- Lead developer
- Mercurna
- Modality
- mRNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Lipid-based Nanoparticles → Nanoparticles → Drug Delivery Systems
- Administration
- Intravenous
01
Overview
mCura1 is an experimental, kidney-targeted mRNA-based therapeutic developed by Mercurna for the treatment of inflammatory kidney diseases, including glomerulonephritis and chronic kidney disease (CKD), as well as for the prevention of delayed graft function in kidney transplantation. The therapeutic consists of a proprietary kidney-homing peptide conjugated to lipid nanoparticles (LNPs) that encapsulate engineered mRNA encoding the anti-inflammatory cytokine Interleukin-10 (IL-10). This targeting mechanism allows for the selective delivery of the mRNA payload to glomerular cells, promoting local expression of IL-10 while minimizing systemic side effects. In preclinical models, mCura1 has demonstrated the ability to significantly reduce proteinuria and inflammatory biomarkers, preserve glomerular architecture, and improve glomerular filtration rate (GFR).
- Other names
- experimental mRNA-based therapeutic
02
Targets
IL10 (Interleukin-10)IL10RA (Interleukin-10 Receptor)
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