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MDC-007
- Development stage
- Preclinical
- Lead developer
- MediciBio
- Modality
- Chemically Modified siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Conjugated siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, mRNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Lipid-based Nanoparticles → Nanoparticles → Drug Delivery Systems
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Overview
MDC-007 is an actively targeted lipid nanoparticle (LNP) delivery system developed by MediciBio. It utilizes antibody or aptamer ligand conjugation to achieve cell-specific delivery of mRNA or siRNA payloads. The platform is designed to target a variety of cell types, including cancer cells and immune cells such as T cells, monocytes, macrophages, and natural killer (NK) cells. Its primary applications include cancer therapies, immunotherapies, and the generation of in vivo CAR therapies, where genetic instructions are delivered directly to immune cells to enable targeted anti-tumor activity.
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