Drug intelligence / Profile preview

MDH-011

Development stage: Unknown
Lead developer: MD Healthcare
Modality: Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Lipid-based Nanoparticles → Nanoparticles → Drug Delivery Systems, Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics
Administration: Oral

Overview

MDH-011 is a microbial extracellular vesicle (EV)-based therapeutic under development by MD Healthcare. It is designed as a freeze-dried oral formulation for the treatment of idiopathic pulmonary fibrosis (IPF), viral pneumonia, and nosocomial pneumonia. MD Healthcare's platform utilizes bacteria-derived extracellular vesicles (also known as outer membrane vesicles or membrane vesicles) to modulate immune and inflammatory pathways, targeting cellular organelles such as mitochondria, endoplasmic reticulum (ER), and peroxisomes to restore homeostasis. MDH-011 has completed preclinical pharmacology and toxicology studies and is in Phase 1 clinical development.

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