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MDH-015

Development stage: Unknown
Lead developer: MD Healthcare
Modality: Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Lipid-based Nanoparticles → Nanoparticles → Drug Delivery Systems, Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics
Administration: Ophthalmic

Overview

MDH-015 is a microbial extracellular vesicle (EV) nanotherapeutic developed by MD Healthcare for the treatment of retinal diseases, including dry age-related macular degeneration (dry AMD), wet age-related macular degeneration (wet AMD), and diabetic retinopathy (DR). The therapeutic is based on MD Healthcare's proprietary platform that utilizes EVs derived from the microbiome to modulate disease pathways. Clinical development for MDH-015 reached the completion of Phase 1 in the fourth quarter of 2023, with Phase 2 trials projected to commence in the fourth quarter of 2026.

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