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MDH-091
- Development stage
- Unknown
- Lead developer
- MD Healthcare
- Modality
- Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Lipid-based Nanoparticles → Nanoparticles → Drug Delivery Systems, Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics
01
Overview
MDH-091 is an investigational microbial extracellular vesicle (EV)-based therapeutic being developed by MD Healthcare for the treatment of atopic asthma and allergic rhinitis. Derived from commensal bacteria, microbial EVs act as key intercellular messengers that can modulate host immune responses. MDH-091 is designed to target the underlying inflammatory pathways of allergic airway diseases, offering a potential non-invasive, next-generation biological treatment option. The candidate is currently in Phase 1 clinical development, with Phase 2 trials planned to initiate in early 2028.
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