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MDH-112
- Development stage
- Unknown
- Lead developer
- MD Healthcare
- Modality
- Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Lipid-based Nanoparticles → Nanoparticles → Drug Delivery Systems, Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics
01
Overview
MDH-112 is a microbial extracellular vesicle (EV)-based therapeutic being developed by MD Healthcare. It is designed for the treatment of non-alcoholic steatohepatitis (NASH), chronic kidney disease (CKD), and coronary artery disease (CHD). MDH-112 utilizes MD Healthcare's proprietary MD ICON and MD Nano Drone platforms to isolate and manufacture therapeutic extracellular vesicles derived from beneficial microbes. The drug is currently in Phase 1 clinical development, with Phase 2 trials planned for late 2027.
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