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MDH-245

Development stage: Unknown
Lead developer: MD Healthcare
Modality: Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Lipid-based Nanoparticles → Nanoparticles → Drug Delivery Systems, Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics
Administration: Ophthalmic

Overview

MDH-245 is a microbial extracellular vesicle (EV) nanotherapeutic being developed by MD Healthcare for the treatment of retinal diseases, including dry age-related macular degeneration (Dry AMD), wet age-related macular degeneration (Wet AMD), and diabetic retinopathy (DR). The drug utilizes MD Healthcare's proprietary platform technology, which leverages extracellular vesicles derived from microbes to deliver therapeutic effects. As of early 2024, MDH-245 is in the early stages of development, with Phase 1 clinical trials projected to begin in the fourth quarter of 2025 and Phase 2 trials expected in late 2028.

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