Drug intelligence / Profile preview

MDK-202

Development stage: Preclinical
Lead developer: Medikine
Modality: Peptides, Fc-Fusion Proteins → Carrier/Scaffold Proteins → Recombinant Proteins and Enzymes
Administration: Subcutaneous, Intravenous

Overview

MDK-202 is an investigational **Fc-peptide fusion biologic** developed by Medikine for immuno-oncology. It is an empirically designed synthetic peptidyl agonist of the **interleukin-2/interleukin-15 receptor beta-gamma-c complex**, engineered to activate IL-2/15Rbeta gammac with subnanomolar potency and full efficacy while avoiding interaction with the IL-2 receptor alpha chain. The active peptide component has been described as MDK1169, a sequence unrelated to native IL-2 or IL-15, and fusion to an Fc domain was used to extend half-life for systemic exposure. Based on the provided sources, MDK-202 is intended as a cytokine-pathway agonist for potential cancer immunotherapy applications.

Other names: MDK1169 Fc fusionMDK-1169 Fc fusionMDK 1169 Fc fusion

Targets

IL2RG (Interleukin-2 receptor gamma subunit)IL2RB (IL-2 receptor beta chain)

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