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MDN-001

Development stage
Phase 1
Lead developer
Suzhou Medinuoyi Medical Technology
Modality
Alpha Emitters → Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Beta Emitters → Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics
Administration
Intra-arterial
01

Overview

MDN-001 is a radiopharmaceutical product consisting of Yttrium-90 (Y-90) microspheres, developed by Suzhou Mednovo Yi Medical Technology Co., Ltd. It is designed for the treatment of patients with unresectable primary hepatocellular carcinoma (HCC) through selective internal radiation therapy (SIRT). The microspheres are administered via the hepatic artery, where they lodge in the microvasculature of the tumor. Once embedded, the Yttrium-90 isotope emits high-energy beta radiation over a short range, delivering a concentrated dose of ionizing radiation directly to the malignant cells to induce DNA damage and tumor necrosis while sparing the surrounding healthy liver parenchyma.

Other names
MDN-001 InjectionMDN001 InjectionMDN 001 InjectionYttrium-90 Microsphere InjectionYttrium90 Microsphere InjectionYttrium 90 Microsphere InjectionY-90 MicrospheresY90 MicrospheresY 90 Microspheres
02

Targets

DNA

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