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MDX1201-A488
- Development stage
- Phase 1
- Lead developer
- City of Hope Medical Center
- Modality
- Light/Condition-Responsive Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Monoclonal Antibodies → Antibody-Based Therapeutics
- Administration
- Intravenous
01
Overview
MDX1201-A488 is a recombinant, human monoclonal antibody that targets an extracellular epitope of human prostate specific membrane antigen (PSMA). It is conjugated with a fluorescent dye (A488), enabling intra-operative optical imaging. The agent is designed to bind specifically to PSMA-expressing cells, such as those found in prostate cancer, and the attached fluorophore allows surgeons to visualize tumor tissue during procedures like robotic-assisted laparoscopic prostatectomy. This targeted imaging approach aims to improve tumor localization and surgical outcomes by providing real-time visualization of cancerous tissue[2][6][8].
- Other names
- anti-PSMA monoclonal antibody MDX1201-A488
02
Targets
PSMA (Prostate-specific membrane antigen)
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