ME1 overexpression TILs

**ME1 overexpression TILs** are tumor-infiltrating lymphocytes (TILs) genetically engineered to overexpress **ME1** (malic enzyme 1), a metabolic enzyme that converts malic acid to pyruvic acid, generating NADPH to support redox balance, lipid synthesis, and metabolic fitness in T cells. This modification enhances the cytotoxicity, resilience, and anti-tumor efficacy of TILs, particularly in immunosuppressive tumor microenvironments, by improving their ability to withstand metabolic stress and maintain effector functions. Developed as an adoptive cell therapy, it shows promise as a salvage strategy for advanced solid tumors, building on TIL successes in melanoma while addressing limitations like T-cell exhaustion.