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measles vaccine
- Development stage
- Unknown
- Lead developer
- Bandim Health Project
- Modality
- Live Attenuated Vaccines → Live Vaccines → Prophylactic Vaccines → Vaccines & Immunotherapeutics
- Administration
- Subcutaneous
01
Overview
The measles vaccine is a live-attenuated viral vaccine primarily used for the prevention of measles infection. In the context of the Bandim Health Project's MATVAC trial in Guinea-Bissau, this vaccine is being evaluated for its "non-specific effects" (NSEs)—the ability to reduce mortality and morbidity from infections other than the target pathogen. The study investigates the impact of maternal vaccination with live vaccines (measles and BCG) on the health and immunity of both the mother and her infant. It explores the hypothesis that these vaccines can strengthen the immune system against a broad range of infectious diseases through mechanisms such as trained innate immunity, potentially providing a survival benefit in high-mortality settings.
- Brand names
- AttenuvaxRouvaxM-VacMeasles Vaccine Live
- Other names
- live-attenuated measles vaccinematernal measles vaccine
02
Targets
SLAMF1 (SLAM family member 1)IFIH1 (MDA5)PVRL4 (Nectin cell adhesion molecule 4)CD46 (CD46 Molecule)
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