Drug intelligence / Profile preview

measles virus vaccine live attenuated

Development stage
Approved
Lead developer
Merck
Modality
Live Attenuated Vaccines → Live Vaccines → Prophylactic Vaccines → Vaccines & Immunotherapeutics
Administration
Subcutaneous, Intramuscular
01

Overview

Measles virus vaccine live attenuated is a biologic immunizing agent used to prevent infection by the measles (rubeola) virus. It consists of a weakened (attenuated) form of the measles virus, typically derived from the Enders' Edmonston strain and propagated in chick embryo cell culture. The vaccine stimulates active immunity by inducing the body to produce protective antibodies against the measles virus, thereby preventing disease upon exposure. While monovalent formulations were previously available (e.g., Attenuvax), most current vaccines are combination products such as M-M-R II or PRIORIX, which also protect against mumps and rubella. The primary indication is for active immunization in children 12 months of age and older, but it may be used earlier in special circumstances. The main route of administration is subcutaneous or intramuscular injection[3][5][7].

Brand names
AttenuvaxM-M-R IIPRIORIXProQuad
Other names
measles vaccine live attenuatedrubeola vaccine live attenuated
02

Targets

STAT2STAT1 (Signal transducer and activator of transcription protein 1)PVRL4 (Nectin cell adhesion molecule 4)CD46 (CD46 Molecule)SLAMF1 (SLAM family member 1)

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