mecamylamine + antidepressant

**mecamylamine + antidepressant** refers to the combination of the nicotinic acetylcholine receptor antagonist **mecamylamine** with an **antidepressant**, typically a selective serotonin reuptake inhibitor (SSRI) or another established antidepressant medication, as an experimental therapeutic approach for treatment-resistant depression. Mecamylamine, originally used for hypertension, blocks nicotinic acetylcholine receptors and has been studied for its potential to augment antidepressant effects, particularly as an adjunct in patients who have not responded to SSRIs alone. Preclinical and early clinical evidence suggest that mecamylamine can enhance serotonergic neurotransmission and may potentiate or alter the efficacy of antidepressants[2][6][7].