Meclofenamic acid

Meclofenamic acid is a nonsteroidal anti-inflammatory drug (NSAID) of the anthranilic acid derivative (fenamate) class, used to treat mild to moderate pain, primary dysmenorrhea, heavy menstrual blood loss, rheumatoid arthritis, and osteoarthritis. It acts primarily by inhibiting cyclooxygenase (COX-1 and COX-2), thereby reducing prostaglandin synthesis. Additionally, it inhibits human leukocyte 5-lipoxygenase activity and antagonizes tissue responses to certain prostaglandins. The drug was developed by Parke-Davis in the 1960s and approved for use in humans in 1980. It is available as meclofenamate sodium under the brand name Meclomen but is not widely used due to a high rate of gastrointestinal side effects[1][2][4][6].

Brand names

Meclomen

Other names

meclofenamate sodium