Drug intelligence / Profile preview

MEDI8852 + oseltamivir

Development stage
Unknown
Lead developer
MedImmune
Modality
Monoclonal Antibodies → Antibody-Based Therapeutics, Small Molecules
Administration
Intravenous, Oral
01

Overview

**MEDI8852 + oseltamivir** is a combination therapy evaluated for the treatment of acute, uncomplicated influenza A infection in adults. MEDI8852 is a human IgG1 kappa monoclonal antibody that broadly targets the hemagglutinin (HA) stem region of influenza A viruses, inhibiting viral entry and fusion. Oseltamivir is a small-molecule neuraminidase inhibitor that prevents the release of new virions from infected cells. This combination is investigated to determine whether joint administration provides improved safety or efficacy compared to either agent alone. Clinical studies have shown the combination to be generally well tolerated, but with no significant additional clinical benefit over monotherapy in uncomplicated influenza A infection[1][4].

Other names
MEDI8852 + Tamiflu
02

Targets

HA stem (Influenza A hemagglutinin stem region)Neuraminidase

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