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MEDI8968
- Development stage
- Discontinued
- Lead developer
- AstraZeneca
- Modality
- Monoclonal Antibodies → Antibody-Based Therapeutics
- Administration
- Subcutaneous
01
Overview
MEDI8968 is a fully human monoclonal antibody that targets the interleukin-1 receptor type 1 (IL-1R1). Developed by AstraZeneca through its MedImmune subsidiary, the drug was designed to block the signaling of interleukin-1 alpha (IL-1α) and interleukin-1 beta (IL-1β), cytokines that play a central role in the inflammatory response. It was primarily evaluated for the treatment of moderate to severe hidradenitis suppurativa (HS) and chronic obstructive pulmonary disease (COPD). In a Phase IIa study for HS, MEDI8968 failed to show a statistically significant improvement in clinical response compared to placebo, leading to the cessation of development for this indication.
- Other names
- anti-IL-1R1 antibodyanti-IL1R1 antibodyanti-IL 1R1 antibody
02
Targets
IL1R1 (Interleukin-1 Receptor Type 1)
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