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Drug intelligence / Profile preview
Medical marijuana, in the context of research conducted by Colorado State University, refers to the use of specific strains of the *Cannabis sativa* plant characterized by varying ratios of delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD). This specific investigational program evaluates the impact of three distinct potency profiles—high CBD/low THC, high THC/low CBD, and balanced THC/CBD—on motor and cognitive functions in patients with multiple sclerosis (MS). THC acts primarily as a partial agonist at the CB1 and CB2 cannabinoid receptors, which are involved in modulating pain, muscle spasticity, and inflammation. CBD is a non-psychoactive cannabinoid that modulates the endocannabinoid system and various non-cannabinoid receptors, potentially providing neuroprotective and anti-inflammatory benefits while mitigating the psychoactive side effects of THC. The goal of the Colorado State University study is to provide evidence-based data on the safety and efficacy of different cannabinoid ratios for managing MS symptoms.
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