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Medrogestone
- Development stage
- Discontinued
- Lead developer
- Pfizer
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Medrogestone is a synthetic progestin medication that functions as an agonist of the progesterone receptor, mimicking the effects of natural progesterone. It has been utilized in menopausal hormone therapy and for various gynecological disorders, including amenorrhea and menstrual irregularities. Historically, it was also employed in the treatment of endometrial cancer, breast cancer, and benign prostatic hyperplasia. Medrogestone is orally active and exhibits weak antiandrogenic, glucocorticoid, and antimineralocorticoid activities.
- Brand names
- ColproneAyerlutonColproColpronEtogynProthilPresomen
- Other names
- MetrogestoneMedrogesterone6,17α-Dimethyl-6-dehydroprogesterone6,17α-Dimethyl-4,6-pregnadiene-3,20-dione
02
Targets
PR (Progesterone receptor)SRD5A (Steroid 5-alpha-reductase)3β-HSD (3β-Hydroxysteroid Dehydrogenase/Δ5-4 isomerase type 1)
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