Drug intelligence / Profile preview

Medtronic IN.PACT

Development stage
Unknown
Lead developer
Medtronic - MITG
Modality
Small Molecules
Administration
Intravascular, Intra-arterial, Intralesional
01

Overview

Medtronic IN.PACT refers to a family of drug-coated balloon (DCB) catheters used in percutaneous transluminal angioplasty (PTA) procedures for the treatment of peripheral artery disease and obstructive lesions in arteriovenous dialysis fistulae. The primary mechanism involves physical dilation of the vessel lumen with a balloon catheter that is coated with paclitaxel and an excipient (urea), enabling local delivery of the antiproliferative agent directly to the vessel wall. This reduces neointimal hyperplasia and restenosis following angioplasty. The device is available in several versions—IN.PACT Admiral for femoropopliteal disease and de novo or restenotic lesions; IN.PACT 018 for similar indications but compatible with smaller guidewires; and IN.PACT AV specifically indicated for use in native arteriovenous dialysis fistulae[1][3][4]. All are developed by Medtronic.

Brand names
IN.PACT AdmiralIN.PACT 018IN.PACT AV
Other names
Medtronic IN.PACT drug-coated balloonMedtronic paclitaxel-coated PTA balloon catheter
02

Targets

TUBB (Tubulin (alpha and beta subunits))

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