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MEE-SA01
- Development stage
- Preclinical
- Lead developer
- Massachusetts Eye and Ear
- Modality
- Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics
- Administration
- Intravitreal, Ophthalmic
01
Overview
MEE-SA01 is a novel Rosenblumvirus bacteriophage being developed for the treatment of Staphylococcus aureus infections, including endophthalmitis and keratitis. It targets and lyses S. aureus, including biofilm-forming clinical isolates. In preclinical studies, MEE-SA01 has demonstrated rapid in vitro antimicrobial and antibiofilm activity against both log- and stationary-phase planktonic cells, and has shown synergistic effects when used sequentially with vancomycin to disrupt biofilms formed on intraocular lenses (IOLs).
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