Drug intelligence / Profile preview

Mefmet-DS

Development stage
Unknown
Lead developer
MetaneX Life Science
Modality
Small Molecules
Administration
Oral
01

Overview

Mefmet-DS is a combination pharmaceutical product marketed by MetaneX Life Science, an Indian generic pharmaceutical company. It is typically formulated as an oral suspension or tablet and contains two active ingredients: Mefenamic acid and Metronidazole. Mefenamic acid is a nonsteroidal anti-inflammatory drug (NSAID) that acts by inhibiting the cyclooxygenase enzymes (COX-1 and COX-2), thereby reducing the synthesis of prostaglandins responsible for pain and inflammation. Metronidazole is a nitroimidazole anti-infective agent that targets anaerobic bacteria and protozoa; it works by forming cytotoxic intermediate radicals that cause DNA strand breakage and inhibit nucleic acid synthesis. Mefmet-DS is primarily indicated for the treatment of mixed gastrointestinal infections, such as amoebic dysentery and bacterial diarrhea, where it simultaneously addresses the underlying infection and the associated abdominal pain and cramps.

Brand names
Mefmet-DS
Other names
Mefenamic acid + Metronidazole
02

Targets

PTGS2 (Prostaglandin-Endoperoxide Synthase 2)NLRP3 (Nod-like receptor family pyrin domain-containing protein 3)PTGER (Prostaglandin E2 receptor)PGHS-1 (Prostaglandin G/H Synthase 1)

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