Drug intelligence / Profile preview

megestrol acetate + testosterone enanthate

Development stage
Unknown
Lead developer
Roche
Modality
Small Molecules
Administration
Oral, Intramuscular, Transdermal, Topical, Subcutaneous, Intranasal
01

Overview

Megestrol acetate + testosterone enanthate is a combination of two pharmaceutical agents. Megestrol acetate is a synthetic progestin with antineoplastic and appetite-stimulating properties. It acts primarily as an agonist at the progesterone receptor and has antigonadotropic effects that suppress gonadal steroid production[1][2][5]. It is used for the treatment of anorexia and cachexia (wasting syndrome), as well as in palliative care for certain cancers such as breast cancer[1][2][8]. Testosterone enanthate is an esterified form of testosterone used primarily in hormone replacement therapy for male hypogonadism; it acts as an androgen receptor agonist to restore or supplement endogenous testosterone levels[6]. The combination has been studied to counteract the suppression of endogenous testosterone caused by megestrol acetate during treatment for wasting conditions; co-administration can help maintain or increase serum testosterone levels while providing the anabolic and appetite-stimulating benefits of both drugs[4].

Brand names
MegaceAndrodermAndroGelFortestaTestimTestopelNatestoVogelxoJatenzoTlandoKyzatrex
02

Targets

PR (Progesterone receptor)AR (Adrenergic receptors)

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