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Drug intelligence / Profile preview
Megex-I ES Suspension
- Development stage
- Unknown
- Lead developer
- Daewon Pharm
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Megex-I ES Suspension (DW5221-R) is a nanosuspension formulation of megestrol acetate developed by Daewon Pharmaceutical. Megestrol acetate is a synthetic derivative of progesterone with potent progestational and antineoplastic activity. In the context of anorexia and cachexia, it acts as an appetite stimulant, likely through the modulation of neuropeptide Y in the hypothalamus and the inhibition of inflammatory cytokines like IL-1, IL-6, and TNF-alpha. This nanosuspension formulation is designed to enhance the bioavailability of megestrol acetate, particularly in the fasted state, compared to traditional formulations. It is primarily indicated for the treatment of loss of appetite and weight loss in patients with cancer or AIDS.
- Brand names
- Megex-I ES Suspension
- Other names
- Daewon Megestrol ES suspensionDW5221-RDW-5221-RDW 5221-R
02
Targets
GR (Glucocorticoid receptor)ABCB1 (P-glycoprotein)PR (Progesterone receptor)
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