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Mehovir
- Development stage
- Unknown
- Lead developer
- Takata Seiyaku
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Mehovir (メホビル配合錠) is a generic fixed-dose combination (FDC) tablet developed and manufactured by Takata Seiyaku for the treatment of HIV-1 infection. It is a generic version of Gilead Sciences' Stribild. The medication consists of four active ingredients: elvitegravir, an HIV-1 integrase strand transfer inhibitor (INSTI); cobicistat, a mechanism-based inhibitor of cytochrome P450 3A (CYP3A) used as a pharmacokinetic enhancer; emtricitabine, a nucleoside reverse transcriptase inhibitor (NRTI); and tenofovir disoproxil fumarate, a nucleotide reverse transcriptase inhibitor (NtRTI). By combining these agents, Mehovir provides a complete antiretroviral regimen in a single daily tablet, targeting both the integration and reverse transcription steps of the HIV viral life cycle.
- Brand names
- Mehovir
- Other names
- Mehovir Combination Tabletsメホビル配合錠
02
Targets
Integrase allosteric pocket (HIV)CYP3A (CYP3A family)Human immunodeficiency virus type 1 reverse transcriptase
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