Drug intelligence / Profile preview

melaleuca alternifolia leaf

Development stage
Unknown
Modality
Small Molecules
Administration
Topical
01

Overview

Melaleuca alternifolia leaf refers to the leaves of the Australian native plant commonly known as tea tree. The essential oil derived from these leaves, known as tea tree oil, is obtained by steam distillation and is widely used in over-the-counter topical products for its antiseptic, anti-inflammatory, broad-spectrum antimicrobial, and antioxidant properties. The primary active component is terpinen-4-ol, which disrupts microbial cell membranes and inhibits inflammatory mediator production such as TNF-alpha and interleukins. It has been studied for use in conditions like acne vulgaris, athlete’s foot (tinea pedis), nail fungus (onychomycosis), seborrheic dermatitis, chronic gingivitis, MRSA colonization prevention/treatment, minor cuts/scrapes/burns protection against infection. Oral ingestion is contraindicated due to toxicity[1][5][8].

Other names
Melaleuca Alternifolia (Tea Tree) LeafMelaleuca Alternifolia (Tea Tree) Leaf ExtractMelaleuca Alternifolia (Tea Tree) Leaf PowderNarrow-leaved Paperbark LeafNarrow-leaved Tea-tree LeafNarrow-leaved Ti-tree LeafSnow-in-summer LeafTea Tree

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