Drug intelligence / Profile preview

Melaxamine

Development stage
Unknown
Lead developer
Grand Medical Group
Modality
Small Molecules
Administration
Oral
01

Overview

Melaxamine is an oral dietary supplement developed by Grand Medical Group, formulated as a combination of melatonin (3 mg) and L-glycine (400 mg). It is designed to support healthy sleep and nervous system function, particularly in individuals experiencing difficulty falling asleep, frequent night awakenings, circadian rhythm disruptions, jet lag, stress, and vegetative-vascular disorders (such as those associated with menopause). Melatonin acts as an agonist at melatonin receptors MT1 and MT2 to regulate the sleep-wake cycle and circadian rhythms. L-glycine serves as an inhibitory neurotransmitter that binds to glycine receptors and acts as a co-agonist at NMDA receptors, promoting emotional balance, reducing anxiety, and facilitating relaxation. Melaxamine is marketed in capsule form and is approved as a health supplement in several European and Eurasian countries.

Brand names
MelaxaminMelaxamin LMelaxamineMelaxamine-L
Other names
melatonin + L-glycinemelatonin + glycine
02

Targets

Glycine receptorMTNR1A (MT1)MTNR1B (Melatonin Receptor 2)NMDAR (Glutamate receptor ionotropic, NMDA)

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