Drug intelligence / Profile preview

melitracen

Development stage
Phase 1
Lead developer
Lundbeck
Modality
Small Molecules
Administration
Oral
01

Overview

Melitracen is a tricyclic antidepressant (TCA) used primarily for the treatment of depression, anxiety, and asthenia. It acts by inhibiting the reuptake of norepinephrine and serotonin at presynaptic terminals, thereby increasing their concentrations in the synaptic cleft and producing an antidepressant effect. Its mechanism of action is similar to other TCAs such as amitriptyline and imipramine. Compared to older TCAs, melitracen may have a faster onset of action and improved tolerability. It is marketed both as a single agent and in combination with flupentixol (as Deanxit) for mood disorders including depression associated with anxiety or agitation[1][3][5][7].

Brand names
MelitracenAdelaxSensitRenxitMelixolMelanxitBenzitLeanxitDanxipressAmilaxAngentaEXZILORMocalmDanxit
Other names
melitracenemélitracènemelitracenomelitracen hydrochloride
02

Targets

SERT (Sodium-dependent serotonin transporter)NET (Norepinephrine Transporter)

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