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Menactra + Adacel + saline
- Development stage
- Unknown
- Lead developer
- Pfizer
- Modality
- Vaccines & Immunotherapeutics
- Administration
- Intramuscular
01
Overview
This combination refers to a specific active control regimen used in clinical research, consisting of the quadrivalent meningococcal conjugate vaccine **Menactra** (MCV4) and the tetanus, diphtheria, and acellular pertussis booster vaccine **Adacel** (Tdap), administered concomitantly with a saline injection. This regimen was utilized as a comparator arm in a Phase 2 clinical trial (NCT01461993) sponsored by **Pfizer** to evaluate the safety and immunogenicity of the bivalent rLP2086 meningococcal group B vaccine (**Trumenba**) when given alongside routine adolescent vaccinations. Menactra provides protection against *Neisseria meningitidis* serogroups A, C, Y, and W-135, while Adacel provides booster immunity against tetanus, diphtheria, and pertussis. In this specific study context, the saline injection served as a placebo for the investigational meningococcal group B vaccine component.
- Brand names
- Menactra + Adacel + saline
- Other names
- MCV4 + Tdap + salineMCV4 + Tdap + saline-Pfizer-meningococcal group B disease
02
Targets
NmA CPS (Neisseria meningitidis group A capsular polysaccharide)PT (Pertussis toxin)TT (Tetanus toxoid)Group Y CPS (Neisseria meningitidis group Y capsular polysaccharide)PRN (Pertactin)FIM2/FIM3 (Fimbriae types 2 and 3)Neisseria meningitidis group C capsular polysaccharideMenW CPS (Neisseria meningitidis serogroup W capsular polysaccharide)Diphtheria toxin
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