Drug intelligence / Profile preview

menadione sodium bisulfite

Development stage
Unknown
Modality
Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules
Administration
Oral, Intravenous, Intramuscular
01

Overview

Menadione sodium bisulfite is a **synthetic, water-soluble derivative of vitamin K** (specifically, vitamin K3) used primarily for **treatment and prevention of vitamin K deficiency**, particularly where oral intake of vitamin K1 or K2 is not feasible or is ineffective. It acts as a **vitamin K precursor**, aiding in the hepatic synthesis of active clotting factors (II, VII, IX, X) and anticoagulant proteins, and is used both in **human and veterinary medicine** for the prevention of bleeding disorders. Its mechanisms include the restoration of vitamin K-dependent carboxylation needed for functional coagulation proteins. It is also used in dietary supplements, food fortification, and animal feed, as well as in research settings for studying vitamin K biochemistry, and occasionally in cosmetics for its antioxidant and cell-reparative properties.

Brand names
BIOVIT XTCADISPER CRUDREN CKSTYPTOCIDTORAINSE-4GTORAINSE4GTORAINSE 4GStypindonMenacureReokayPhytokickKewinMenodioneRvit KHindustan
Other names
menadione sodium bisulphitemenadione sodium bisulphate2-methyl-1,4-naphthoquinone sodium bisulfite
02

Targets

GGCX (Vitamin K-dependent gamma-glutamyl carboxylase)VKORC1 (Vitamin K epoxide reductase complex subunit 1)F9 (Coagulation Factor IX)F7 (Coagulation Factor VII)F10 (Factor Xa)F2 (Thrombin)

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