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menaquinone-7
- Development stage
- Phase 2
- Lead developer
- NattoPharma
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Menaquinone-7 is a long-chain form of vitamin K2 characterized by seven isoprene units in its side chain. It acts as a cofactor in the carboxylation of specific proteins required for blood clotting and bone metabolism. Menaquinone-7 has demonstrated roles in promoting bone health, cardiovascular health, and possibly modulating inflammation through various signal transduction pathways such as PI3K/AKT, MAP kinase, JAK/STAT, and NF-kB. It cannot be synthesized by the human body and must be obtained from dietary sources or supplements; natural food content is low so supplementation is common for biomedical applications. Menaquinone-7 exhibits higher bioavailability and longer half-life compared to other forms of vitamin K2 (such as MK-4). Clinical trials have investigated its effects on osteocalcin carboxylation and bone density conservation[1][3][5][6].
- Brand names
- MenaQ7MenaQ-7MenaQ 7
- Other names
- MK-7MK7MK 7vitamin K2-7vitamin K2 (menaquinone-7)
02
Targets
GGCX (Vitamin K-dependent gamma-glutamyl carboxylase)
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