Clinical trials
Full profile accessFollow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
menatetrenone disodium diphosphate
- Development stage
- Unknown
- Lead developer
- Zhuohe Pharmaceutical
- Modality
- Small Molecules
- Administration
- Parenteral
01
Overview
Menatetrenone disodium diphosphate is a water-soluble, injectable small molecule analogue of vitamin K2 (menatetrenone, also known as MK-4). Developed by Guangdong Aimin Pharmaceutical Co., Ltd., it serves as a cofactor for the enzyme gamma-glutamyl carboxylase, which is essential for the post-translational gamma-carboxylation of glutamate residues in vitamin K-dependent proteins. This process is critical for the activation of coagulation factors II (prothrombin), VII, IX, and X, making the drug a potential therapeutic for hypoprothrombinemia and biliary colic. The disodium diphosphate salt formulation allows for parenteral administration, overcoming the solubility limitations of natural fat-soluble vitamin K2. It is currently in Phase 1 clinical development in China, with studies focused on characterizing its pharmacokinetic profile, safety, and dose linearity in healthy adult volunteers.
- Other names
- menatetrenone disodium diphosphatevitamin K2 disodium diphosphatemenatetrenone sodium diphosphate
02
Targets
GGCX (Vitamin K-dependent gamma-glutamyl carboxylase)
Beyond the preview
Go deeper on menatetrenone disodium diphosphate.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Full profile accessExplore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Full profile accessTrace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Full profile accessExplore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Full profile accessCompare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Full profile accessConnect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on menatetrenone disodium diphosphate.