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MenBvac is an outer membrane vesicle vaccine developed to prevent systemic meningococcal disease caused by serogroup B Neisseria meningitidis. Clinical studies have demonstrated that a four-dose regimen (three primary doses 6 weeks apart followed by a fourth booster dose a year later) provides good immunogenicity with prolonged persistence and increased cross-reactivity of functional antibodies. The vaccine has shown an acceptable safety profile with mild to moderate local and systemic reactions.
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