Drug intelligence / Profile preview

meningococcal (groups A, C, W, Y) conjugate vaccine (tetanus toxoid carrier) + pneumococcal 13-valent conjugate vaccine

Development stage
Unknown
Lead developer
Sanofi
Modality
Vaccines & Immunotherapeutics
Administration
Intramuscular
01

Overview

This combination refers to the co-administration of the quadrivalent meningococcal conjugate vaccine (MenACWY-TT) and the 13-valent pneumococcal conjugate vaccine (PCV13). MenACWY-TT, marketed as MenQuadfi by Sanofi or Nimenrix by Pfizer, is a conjugate vaccine where capsular polysaccharides from Neisseria meningitidis serogroups A, C, W, and Y are covalently linked to a tetanus toxoid carrier protein. PCV13, marketed as Prevnar 13 by Pfizer, contains capsular polysaccharides from 13 serotypes of Streptococcus pneumoniae (1, 3, 4, 5, 6A, 6B, 7F, 9V, 14, 18C, 19A, 19F, and 23F) conjugated to a non-toxic mutant of diphtheria toxin (CRM197). The co-administration of these vaccines is common in pediatric and geriatric immunization schedules. Clinical trials have demonstrated that simultaneous administration at separate injection sites maintains the immunogenicity and safety profile of each individual vaccine, providing broad protection against invasive meningococcal and pneumococcal diseases.

Other names
meningococcal (groups A, C, W, Y) conjugate vaccine + pneumococcal 13-valent conjugate vaccineMenACWY-TT + PCV13
02

Targets

CPS (Streptococcus pneumoniae capsular polysaccharide)TT (Tetanus toxoid)MenACWY (Neisseria meningitidis capsular polysaccharides serogroups A, C, W, and Y)

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