Drug intelligence / Profile preview

meningococcal (groups A, C, Y and W-135) polysaccharide diphtheria toxoid conjugate vaccine (Sanofi, 883a5a)

Development stage
Unknown
Lead developer
Sanofi
Modality
Vaccines & Immunotherapeutics
Administration
Intramuscular
01

Overview

Menactra is a quadrivalent meningococcal conjugate vaccine developed by Sanofi Pasteur for the prevention of invasive meningococcal disease caused by *Neisseria meningitidis* serogroups A, C, Y, and W-135. Approved by the FDA in 2005, it was the first conjugate vaccine of its kind. The vaccine is composed of capsular polysaccharides from the four serogroups, each individually conjugated to a diphtheria toxoid carrier protein. This conjugation converts the T-cell independent immune response typically seen with polysaccharide vaccines into a T-cell dependent response, which induces immunological memory and higher antibody titers, particularly in young children and adolescents. It is indicated for active immunization in individuals aged 9 months through 55 years and is administered via intramuscular injection.

Brand names
Menactra
Other names
MCV4MCV-4MCV 4MenACWY-Dtetravalent meningococcal diphtheria toxoid conjugate vaccine
02

Targets

NmA CPS (Neisseria meningitidis group A capsular polysaccharide)Neisseria meningitidis group C capsular polysaccharideMenW CPS (Neisseria meningitidis serogroup W capsular polysaccharide)Group Y CPS (Neisseria meningitidis group Y capsular polysaccharide)

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