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meningococcal (groups A, C, Y and W135) polysaccharide conjugate vaccine
- Development stage
- Unknown
- Lead developer
- Beijing Minhai Biological
- Modality
- Vaccines & Immunotherapeutics
- Administration
- Intramuscular
01
Overview
MCV-ACYW135 is a quadrivalent meningococcal conjugate vaccine developed by Beijing Minhai Biotechnology for the prevention of invasive meningococcal disease caused by *Neisseria meningitidis* serogroups A, C, Y, and W135. The vaccine is composed of capsular polysaccharides from these four serogroups, each chemically conjugated to a carrier protein. This conjugation converts the polysaccharide antigens into T-cell dependent antigens, thereby enhancing immunogenicity and inducing immunological memory, which is particularly critical for protection in infants and young children. A Phase 3 clinical trial (NCT02003495) conducted in China evaluated the safety and immunogenicity of the vaccine in healthy children aged 2 months to 6 years, demonstrating its potential to provide broad protection against the most common serogroups associated with meningococcal meningitis.
- Other names
- quadrivalent meningococcal conjugate vaccineMinhai MCV-ACYW135MCV-ACYW135 vaccineMCV-ACYW-135 vaccineMCV-ACYW 135 vaccine
02
Targets
NmA CPS (Neisseria meningitidis group A capsular polysaccharide)Group Y CPS (Neisseria meningitidis group Y capsular polysaccharide)BCR (Immunoglobulin G B Cell Receptor)Neisseria meningitidis group C capsular polysaccharideMenW CPS (Neisseria meningitidis serogroup W capsular polysaccharide)CD4 (T lymphocyte surface antigen)
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